Realign

your expectations of oral enzymes.

Reimagine

how diseases of malabsorption and nutrient metabolism can be treated.

Rethink

what's possible.

We are...

Unlocking

breakthrough orally-delivered enzyme therapeutics engineered for rare, life-threatening diseases.

Purpose

Inspired by the Patients We Aim to Help

Malabsorption Syndromes and Nutrient Metabolism Disorders are a group of disorders caused by enzyme deficiencies or genetic mutations that result in conditions that prevent the body from properly metabolizing or absorbing certain fats, carbohydrates, simple sugars, proteins, vitamins or other key nutrients.

Malabsorption of macronutrients
leads to devastating consequences:

Debilitating
GI Symptoms

Steatorrhea, constipation, nausea, abdominal pain, bloating, gas, diarrhea

Weight Loss and
Growth Impediment

Weight loss, wasting and fatigue are common and pronounced; independent predictor of survival

Fatty Acid, Carbohydrate,
and Protein Abnormalities

Play a central role in severity of symptoms and disease progression

Increased Morbidity and
Reduced QoL

Worsens clinical outcomes; adds to the overall costs of care and dramatic impact to QoL

Reduced Life-Expectancy

Directly impacts survival in rare disease, cancer and pancreatitis

Metabolic Challenges

Increased inflammation, vitamin deficiencies, reduced bone mineral metabolism and ultimately organ failure

These disorders affect many people worldwide, most of whom are
inadequately treated or have no treatment at all. Anagram Therapeutics is committed to changing that.

Anagram is focused on becoming the world's leading biopharmaceutical company developing breakthrough orally-delivered enzymes to treat diseases that have a severe impact on the lives of infants, children and adults as well as their families.

Science

Powered by Innovativations

Our company name is inspired by pioneering technology and reflects our ambition to realign and reimagine orally-delivered enzymes to make a meaningful difference.

Anagram Therapeutics is using our expertise in enzymes and gastrointestinal physiology to drive target selection and design novel products that can become breakthrough treatments.

Through this specific and selective approach, our team of world-class researchers and collaborators is unlocking breakthrough orally-delivered enzyme therapeutics that have the potential to change how Malabsorption Syndromes and Nutrient Metabolism Disorders are treated.

Pipeline

Advancing Best-in-Class Enzyme Therapies

At Anagram, we are developing a deep pipeline of products that use the power of orally-delivered enzymes as therapeutics to solve complex problems.

Candidate
Indication
Discovery & Optimization
Preclinical
IND
Phase 1
Phase 2
Phase 3
ANG003
Exocrine pancreatic insufficiency; malabsorption syndromes
H1:23
+

New class of enzyme replacement therapy providing unparalleled performance with broad-spectrum composition (lipase for fat, protease for protein, amylase for carbohydrate) to make a life-changing impact for people who require oral ERT.

-
ANG011
Congenital Malabsorptive Syndrome
+

Engineered to break down specific carbohydrates due to enzyme deficiencies to avoid the severe complications associated with carbohydrate malabsorption.

-
ANG021
Malabsorptive Syndrome
+

Engineered to break down specific carbohydrates abnormalities due to pancreatic dysfunction to avoid the complications associated with carbohydrate malabsorption.

-
ANG031
Congenital Carbohydrate Malabsorption
+

Engineered to break down specific carbohydrates to avoid buildup in the body of toxic complications associated with carbohydrate malabsorption.

-
ANG003
Candidate
Exocrine pancreatic insufficiency;
malabsorption syndromes
Indication
+
Phase 3
H1:23
Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization
-
Phase 3

New class of enzyme replacement therapy providing unparalleled performance with broad-spectrum composition (lipase for fat, protease for protein, amylase for carbohydrate) to make a life-changing impact for people who require oral ERT.

Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization
ANG011
Candidate
Congenital Malabsorptive Syndrome
Indication
+
Phase 3
Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization
-
Phase 3

Engineered to break down specific carbohydrates due to enzyme deficiencies to avoid the severe complications associated with carbohydrate malabsorption.

Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization
ANG021
Candidate
Malabsorptive Syndrome
Indication
+
Phase 3
Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization
-
Phase 3

Engineered to break down specific carbohydrates abnormalities due to pancreatic dysfunction to avoid the complications associated with carbohydrate malabsorption.

Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization
ANG031
Candidate
Congenital Carbohydrate Malabsorption
Indication
+
Phase 3
Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization
-
Phase 3

Engineered to break down specific carbohydrates to avoid buildup in the body of toxic complications associated with carbohydrate malabsorption.

Phase 2
Phase 1
IND
Preclinical
Discovery & Optimization

People

A Dedicated and Experienced Team

Anagram's team of passionate scientists and biotech leaders are united in our commitment to individuals and families affected by serious rare diseases. We are focused to our core and driven to take on big challenges in our pursuit of big breakthroughs and better therapies.

Together, we are working to turn potential into products, and meaningfully improve the lives of people living with Malabsorption Syndromes and Nutrient Metabolism Disorders.

Take a look at our Management Team and Board of Directors.

Join Our Team

Anagram is looking for team members who are talented, engaged and committed to growing the organization through the work that they do. Join our team of leading scientists, expert drug developers, and biotech industry veterans. We offer competitive salary and benefits, as well as an environment where excellence and creativity make meaningful scientific and medical advances possible.


Contact

Anagram Therapeutics, Inc. | 10 Speen Street | Framingham, MA 01701 617-466-3111

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